Salicylic acid is an important organic synthetic raw material, widely used in medicine, pesticides, dyes, rubber, food and perfume fields. In the pharmaceutical industry, the main pharmaceutical products of salicylic acid are sodium salicylate, Holly oil (methyl salicylate), aspirin (acetylsalicylic acid), salicylic acid amine, phenyl salicylic acid. In the dye industry, it is used to produce mordant pure yellow, direct yellow 3GN, direct Yellow GR, direct Brown 3GN, acid mordant Brown G, acid mordant yellow GG, acid yellow complex dyes
Chemical Properties| Property | Value |
Melting point | 158-161 °C(lit.) |
Boiling point | 211 °C(lit.) |
Density | 1.44 |
Bulk density | 400-500kg/m3 |
Vapor density | 4.8 (vs air) |
Vapor pressure | 1 mm Hg ( 114 °C) |
Refractive index | 1,565 |
FEMA | 3985 | 2-HYDROXYBENZOIC ACID |
Fp | 157 °C |
Storage temp. | 2-8°C |
Solubility | ethanol: 1 M at 20 °C, clear, colorless |
Pka | 2.98(at 25℃) |
Form | Solid |
Color | White to off-white |
PH Range | Non0 uorescence (2.5) to dark blue 0 uorescence (4.0) |
Odor | At 100.00 %. faint phenolic nutty |
PH | 3.21(1 mM solution);2.57(10 mM solution);2.02(100 mM solution); |
Odor Type | nutty |
Biological source | synthetic |
Water Solubility | 1.8 g/L (20 ºC) |
Sensitive | Light Sensitive |
λmax | 210nm, 234nm, 303nm |
Merck | 14,8332 |
JECFA Number | 958 |
Sublimation | 70 ºC |
BRN | 774890 |
Stability | Stable. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Combustible. Sensitive to light. |
Major Application | Semiconductors, nanoparticles, photoresists, lubricating oils, UV absorbers, adhesive, leather, cleaner, hair dye, soaps, cosmetics, pain medication, analgesics, antibacterial agent, treatment of dandruff, hyperpigmented skin, tinea pedis, onychomycosis, osteoporosis, beriberi, fungicidal skin disease, autoimmune disease |
InChIKey | YGSDEFSMJLZEOE-UHFFFAOYSA-N |
LogP | 2.01 |
CAS DataBase Reference | 69-72-7(CAS DataBase Reference) |
NIST Chemistry Reference | Benzoic acid, 2-hydroxy-(69-72-7) |
EPA Substance Registry System | Salicylic acid (69-72-7) |
Safety Information
| Property | Value |
| Hazard symbols | Xn, F |
| Hazard class codes | 22-41-36/37/38-36-20/21/22-11 |
| Safety descriptions | 26-39-37/39-36-36/37-16 |
| UN dangerous goods number | UN 1648 3 / PGII |
| WGK Germany | 1 |
| RTECS number | VO0525000 |
| Autoignition temperature | 500 °C |
| TSCA | TSCA listed |
| HS code | 29182100 |
| Storage class | 11 - Combustible solids |
| Hazard class (category) | Acute toxicity, Category 4, Oral Serious eye damage, Category 1 Reproductive toxicity, Category 2 |
| Hazardous substances data | 69-72-7 (Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 500 mg/kg (Sota) |
Product Usage
Salicylic acid is an organic acid widely used in cosmetics and pharmaceutical applications due to its excellent exfoliating and antibacterial properties. In skincare products, it can penetrate deep into pores to dissolve excess oil and dead skin cells, helping to prevent and reduce acne, blackheads, and blemishes. It is commonly found in cleansers, toners, and anti-acne serums. In the pharmaceutical field, salicylic acid is also used to treat hyperkeratotic skin conditions such as keratosis pilaris and dandruff. While highly effective, it should be used at appropriate concentrations to ensure safety and minimize irritation.