Dimethylformamide is a flammable, colorlessliquid with a fishy, unpleasant, amine-like scent at relativelylow concentrations. The smell threshold is 0.47100 ppm.Molecular weight= 73.11; Specific gravity (H2O:1)= 0.95;Boiling factor = 153℃; Freezing/Melting factor = 261℃;Vapor pressure= three mmHg at 20℃; Flash factor = 58℃;Autoignition temperature= 444.5℃. Explosive limits are:LEL = 2.2%; UEL= 15.2% at 100℃. Hazard Identification(based on NFPA-704 M Rating System): Health 2,Flammability 2, Reactivity zero Soluble in water.Potential Exposure: Tumorigen,Mutagen; Reproductive Effector; Human Data; Hormone,Primary Irritant. DMFA is used as a solvent for liquids,gases, and as a fuel additive. Dimethylformamide haspowerful solvent homes for a broad vary of organiccompounds. Because of its bodily properties, this chemical has been used when solvents with a gradual price of evaporation are required. It finds unique utilization in themanufacture of polyacrylic fibers, butadiene, purified acetylene, pharmaceuticals, dyes, petroleum products, and otherorganic chemicals.
Chemical Properties
| Property | Value |
Melting point | -61 °C (lit.) |
Boiling point | 153 °C (lit.) |
Alpha | 0.94 º |
Density | 0.944 g/mL (lit.) |
Vapor density | 2.5 (vs air) |
Vapor pressure | 2.7 mm Hg ( 20 °C) |
Refractive index | n20/D 1.430(lit.) |
Fp | 136 °F |
Storage temp. | Store at +5°C to +30°C. |
Solubility | Water: miscible |
Pka | -0.44±0.70(Predicted) |
Form | Liquid |
Color | APHA: ≤15 |
Relative polarity | 0.386 |
PH | 7 (200g/l, H2O, 20℃) |
Odor | Faint, ammonia-like odor detectable at 100 ppm |
explosive limit | 2.2-16%(V) |
Odor Threshold | 1.8ppm |
Water Solubility | Soluble |
λmax | λ: 270 nm Amax: 1.00λ: 275 nm Amax: 0.30λ: 295 nm Amax: 0.10λ: 310 nm Amax: 0.05λ: 340-400 nm Amax: 0.01 |
Sensitive | Hygroscopic |
Merck | 14,3243 |
BRN | 605365 |
Exposure limits | NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted). |
Dielectric constant | 36.710000000000001 |
InChIKey | ZMXDDKWLCZADIW - UHFFFAOYSA - N |
LogP | -1.010 |
CAS DataBase Reference | 68-12-2(CAS DataBase Reference) |
IARC | 2A (Vol. 47, 71, 115) 2018 |
NIST Chemistry Reference | Formamide, N,N-dimethyl-(68-12-2) |
EPA Substance Registry System | N,N-Dimethylformamide (68-12-2) |
Safety Information
| Property | Value |
Hazard Codes | T |
Risk Statements | 61-20/21-36 |
Safety Statements | 53-45 |
RIDADR | UN 2265 3/PG 3 |
OEB | A |
OEL | TWA: 10 ppm (30 mg/m3) [skin] |
WGK Germany | 1 |
RTECS | LQ2100000 |
F | 3-10 |
Autoignition Temperature | 445 °C |
Hazard Note | Toxic |
TSCA | Yes |
HazardClass | 3 |
PackingGroup | III |
HS Code | 29241990 |
Hazardous Substances Data | 68-12-2(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch) |
IDLA | 500 ppm |
Product Usage
N,N-Dimethylformamide (DMF) is a versatile high-boiling solvent widely acclaimed as the "universal solvent" due to its exceptional solubility. Its primary application is in the synthetic fiber and resin industry, where it is used to spin polyacrylonitrile fibers and manufacture high-quality synthetic leather (PU). In the pharmaceutical sector, DMF is an indispensable reaction medium for synthesizing vitamins, hormones, and various antibiotics. Additionally, it plays a critical role in the electronics industry for cleaning precision components and in petrochemicals for the selective extraction of acetylene and butadiene.